The areas of the body most likely to be injured during a motorcycle crash include the head, neck, and extremities (arms and legs). The head and neck are particularly vulnerable due to the lack of protection offered by a motorcycle compared to a car. In the event of a crash, a rider can suffer serious head and neck injuries, such as skull fractures, traumatic brain injuries, and spinal cord injuries.

Upper extremities, including the arms and hands, are also at risk of injury in a motorcycle crash, as riders may use their arms and hands to try to break their fall. Lower extremities, such as the legs and feet, are also vulnerable, as they can be crushed or otherwise injured in a crash.

It is important for motorcyclists to wear proper protective gear, such as a helmet, gloves, and sturdy footwear, to minimize the risk of injury in the event of a crash.